ABSTRACT
Ischemic stroke is one of the main diseases which harm the health of the elderly. To promote angiogenesis is of great significance for treating ischemic stroke. In recent years, treatment by TCM based on therapeutic angiogenesis intervention for ischemic stroke has achieved great development. Pharmacological and clinical studies have shown that TCM can promote angiogenesis, thereby improving cerebral ischemia and neurological function. This article reviewed the current situation in this field and provided references for clinical treatment of ischemic stroke.
ABSTRACT
The main active ingredients of Salviae Miltiorrhizae Radix et Rhizoma are water-soluble ingredients and fat-soluble components. Its active ingredients can inhibit the neuronal apoptosis, improve cerebral ischemia, reduce cerebral infarction, and treat Alzheimer's disease, vascular dementia, Parkinson's disease, epilepsy, etc. Its active ingredients play an important role in nervous system, which has attracted more and more attention of scholars both at home and abroad. This article reviewed the roles of Salviae Miltiorrhizae Radix et Rhizoma and its active ingredients in nervous system, which can provide references for relevant research.
ABSTRACT
Herba Cistanche includes a variety of chemical constituents, such as phenylethanoid glycosides, iridoid glycosides and so on. Its effective constituents can inhibit the neuronal apoptosis, reduce ischemic brain injury, treat Alzheimer's disease, Parkinson's disease, vascular dementia, and improve the function of learning and memory. Its effective constituents play an important role in nervous system, which has received more and more attention of scholars both at home and abroad. This article reviewed the effects of effective constituents in Herba Cistanche on nervous system.
ABSTRACT
This study was aimed to explore five Chinese medicine components or ingredients from Qu-Shi Hua-Y u Decoction (QSHYD) with uniform design method and screen ingredients assembling of Chinese medicine BZL pre-scription in order to verify its therapeutic effect on experimental fatty liver rats. High-fat diet was used in the estab-lishment of fatty liver rat models. Five effective ingredients (i.e., chlorogenic acid, geniposide, curcumin, polydatin and polysaccharide of Atractylodes macrocephala Koidz) of QSHYD were used as study subjects. Uniform design was applied in the grouping design. The intragastric administration was given for four weeks. The screening index was the content of liver triglyceride (TG). The ingredients assembling of Chinese medicine BZL prescription was screened through uniform design and regression analysis. The same fatty liver animal model was used in the comparison be-tween QSHYD and rosiglitazone. The TG content in liver tissues of rats and serum ALT activity were detected. The pathological changes of liver tissues were observed (HE stain and oil red O stain) with Ridit analysis to verify its therapeutic effect. The results showed that through screening, the regression equation was Y = 15.083X1 + 5.321X2- 5.186X3 - 16.157X4 + 9.35X5 + 17.667X3X4 - 8.422X1X2 - 6.617X3X5 + 16.571 (X1: chlorogenic acid, X2:polydatin, X3: polysaccharide of Atractylodes macrocephala Koidz, X4: geniposide, X5: curcumin). According to this equation, the best TG reducing effect occurred when the chlorogenic acid (X1), polysaccharide of Atractylodes macrocephala Koidz (X3), and geniposide (X4) were the maximum dosage. It showed that the best combination in inhibiting TG content in liver tissues was X3, X4 and X1 (i.e. BLZ prescription). Among fatty liver rat mod-els induced with same high-fat diet, the screened Chinese medicine ingredient BZL prescription can obviously reduce its TG content in liver tissues and serum ALT activity ( P < 0 . 01 ) . It obviously improved the fatty degen-eration of rat's liver. It was concluded that ingredients assembling of Chinese medicine BZL prescription screened through uniform design can obviously prevent and treat fat deposition and injury of the liver among rat models induced by high-fat diet .
ABSTRACT
The compound of active ingredients of traditional Chinese medicine (TCM),whose material base is relatively clear,adheres to the concept and advantages of formula compatibility of TCM.Thus,it is an important approach to modern TCMresearch.The significance of research on compound of TCMcomponents/ingredients,as well as the research ideas,is sketched out,and the current research on compound of TCMcomponents for the prevention and treatment of liver diseases is reviewed.The research strategies for TCMcomposition/compound for the prevention and treatment of liver diseases are elucidated from the following two aspects:exploring the compound of TCM components based on clinical TCM compound and studying the composition aiming at the effective components or ingredients of TCM that have been known;it is pointed out that the compatibility of effective TCM components,which provides the method and technology system for innovative drug research,is an innovative research model for inheriting and developing the TCMtheory and is one of the important approaches to modern TCM research.
ABSTRACT
This article was aimed to expound current complexity and diversity about Chinese medicine dose-ef-fect relationship . It demonstrated that the study on Chinese medicine dose-effect relationship should be based on clinical effect as its foundation , and be guided by the traditional Chinese medicine ( TCM ) theories . Differ-ent modern science and technology means and methods should be applied for the multi-perspective , multi-lev-el and multidisciplinary systematic study of the Chinese medicine dose-effect relationship .
ABSTRACT
Systems biology, which includes genomics, proteomics, transcriptomics and metabolomics, is an integration of system theory and biology. It studies the life phenomena with thinking method of systems theory. And it provides an important methodological basis and technical conditions for recognizing syndrome of traditional Chinese medicine (TCM) and mechanism of therapeutic effect from multiple disciplines and perspectives. Systems biology is similar to the core idea of TCM system and holism concept. Therefore, systems biology can be used as a platform and pivot of non-alcoholic fatty liver disease (NAFLD) in modern TCM study. Systems biology will accelerate the modernization research of TCM in the prevention and treatment of NAFLD. It will also provide new ideas and methods for TCM study on NAFLD.